Beyond keywords, Transinsight uses novel algorithms, state-of-the art natural language processing, and ontologies to provide better and faster search capabilities for complex queries not only in the life sciences. The goal of this development is the establishment of a semantic web for the life sciences. GoPubMed, the ontology-based literature search engine, is a first example of a knowledge-based semantic search engine to improve searching in sciences. GoPubMed paves the way for a migration from web to semantic web.